THE WINE DOCTOR
Research Articles
Resveratrol – General Information
Podcast
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Through the LIne – Boardroom.media – Episode 24 – Interview with Dean Kilby, Resveratrol
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Resveratrol and health – A comprehensive review of human clinical trials
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Clinical trials of resveratrol
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Resveratrol: French Paradox Revisited
Resveratrol and Cancer
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Inhibition of Cancer Growth by Resveratrol is related to its Low Bioavailability
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Resveratrol and cancer: a review
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Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration
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Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake
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Resveratrol and Cancer: Chemoprevention, Apoptosis, and Chemoimmunosensitizing Activities
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Resveratrol Induces Apoptosis in Chemoresistant Cancer Cells via Modulation of AMPK Signaling Pathway
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Resveratrol and Cancer
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Resveratrol and cancer: focus on in vivoevidence
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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
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Resveratrol in cancer management: where are we and where we go from here?
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Resveratrol Inhibits Cancer Cell Metabolism by Down Regulating Pyruvate Kinase M2 via Inhibition of Mammalian Target of Rapamycin
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Resveratrol and cancer: Challenges for clinical translation
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Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species–Mediated Hypoxia-Inducible Factor-1α Activation
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Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials
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Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent
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Resveratrol: A review of preclinical studies for human cancer prevention
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Chemopreventive effect of resveratrol to cancer
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Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies
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Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms (review)
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Differential Effects on Growth, Cell Cycle Arrest, and Induction of Apoptosis by Resveratrol in Human Prostate Cancer Cell Lines
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Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis
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Cancer Chemopreventive Activity of Resveratrol
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Resveratrol Inhibits Proliferation and Induces Apoptosis in Human Pancreatic Cancer Cells
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Resveratrol Induces Growth Inhibition, S-phase Arrest, Apoptosis, and Changes in Biomarker Expression in Several Human Cancer Cell Lines
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The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1
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Chronic Treatment with Resveratrol Induces Redox Stress- and Ataxia Telangiectasia-mutated (ATM)-dependent Senescence in p53-positive Cancer Cells
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Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
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Resveratrol as an anticancer nutrient: molecular basis, open questions and promises
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Polyphenols and cancer cell growth
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Inhibition of cancer growth by resveratrol is related to its low bioavailability
Breast Cancer
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Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat
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Estrogen and Resveratrol Regulate Rac and Cdc42 Signaling to the Actin Cytoskeleton of Metastatic Breast Cancer Cells
Colo-rectal Cancer
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Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients
Leukemia
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Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells
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Comparative Antiproliferative and Apoptotic Effects of Resveratrol, ϵ-viniferin and Vine-shots Derived Polyphenols (Vineatrols) on Chronic B Lymphocytic Leukemia Cells and Normal Human Lymphocytes
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Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
Chemotherapy
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Resveratrol Imparts Photoprotection of Normal Cells and Enhances the Efficacy of Radiation Therapy in Cancer Cells†
Ovarian/cervical Cancer
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Resveratrol inhibits glucose metabolism in human ovarian cancer cells
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Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells
Pancreatic Cancer
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Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis
Prostrate Cancer
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Modulation of androgen receptor-dependent transcription by resveratrol and genistein in prostate cancer cells
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Mechanisms Involved in Resveratrol-Induced Apoptosis and Cell Cycle Arrest in Prostate Cancer—Derived Cell Lines
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Resveratrol suppresses prostate cancer progression in transgenic mice
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Resveratrol Down-Regulates the Androgen Receptor at the Post-Translational Level in Prostate Cancer Cells
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Non-genomic action of resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway
Resveratrol and Aging
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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice
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Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications
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Resveratrol in prevention and treatment of common clinical conditions of aging
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Effects of resveratrol on lifespan in Drosophila melanogasterand Caenorhabditis elegans
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Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span
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Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation
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Resveratrol Preserves Cerebrovascular Density and Cognitive Function in Aging Mice
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Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease
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Resveratrol and novel potent activators of Sirt1: effects on aging and age-related diseases
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Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties
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Cellular and Behavioural Effects of Stilbene Resveratrol Analogues: Implications for Reducing the Deleterious Effects of Aging
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Resveratrol and the Pharmacology of Aging: A New Vertebrate Model to Validate an Old Molecule
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Small molecule SIRT1 activators for the treatment of aging and age-related diseases
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The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan
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Metabolic Effects of Resveratrol in Mammals – a Link Between Improved Insulin Action and Aging
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Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol
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Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: Protection by chronic oral intake of resveratrol
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Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate
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Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for a healthy aging
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Modulation of SIRT1-Foxo1 Signalling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance
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The effects of resveratrol on aging vessels
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Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signalling pathway
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Resveratrol As Anti-Aging Therapy for Age-Related Bone Loss
Anti Inflammatory
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Resveratrol as an anti-inflammatory and anti-aging agent: Mechanisms and clinical implications
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Vascular Dysfunction in Aging: Potential Effects of Resveratrol, an Anti- Inflammatory Phytoestrogen
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Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease
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Anti-Inflammatory Responses of Resveratrol
Chronic Disease and Inflammation
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Resveratrol: A multitargeted agent for age-associated chronic diseases
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The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model
Vascular Effects
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Vascular Dysfunction in Aging: Potential Effects of Resveratrol, an Anti- Inflammatory Phytoestrogen
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The effects of resveratrol on aging vessels
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Resveratrol: Preventing properties against vascular alterations and ageing
Insulin Hormone
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Metabolic Effects of Resveratrol in Mammals – a Link Between Improved Insulin Action and Aging
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Resveratrol inhibits insulin responses in a SirT1-independent pathway
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Modulation of SIRT1-Foxo1 Signalling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance
Obesity / Calorie Intake
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Resveratrol improves health and survival of mice on a high-calorie diet
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Resveratrol as a calorie restriction mimetic: therapeutic implications
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Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for a healthy aging
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Resveratrol, obesity and diabetes
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Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet
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Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?
Cardiovascular / Vascular
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Cardiovascular Protective Effects of Resveratrol
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Cardiovascular effects and molecular targets of Resveratrol
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Chemo prevention of cancer and cardiovascular disease by Resveratrol.
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Resveratrol in cardiovascular health and disease
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Resveratrol: A Therapeutic Promise for Cardiovascular Diseases
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One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease
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Dietary polyphenols: Focus on resveratrol, a promising agent in the prevention of cardiovascular diseases and control of glucose homeostasis
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Mechanisms of Cardiovascular Protection by Resveratrol
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Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial
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Calorie restriction and resveratrol in cardiovascular health and disease
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Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases
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Significance of wine and resveratrol in cardiovascular disease: French paradox revisited
Diabetes Type 2
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Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
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Resveratrol, obesity and diabetes
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Central Administration of Resveratrol Improves Diet-Induced Diabetes
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Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits?
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Pilot Study of Resveratrol in Older Adults with Impaired Glucose Tolerance
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Anti-diabetic effects of resveratrol
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Resveratrol Attenuates Renal Hypertrophy in Early-Stage Diabetes by Activating AMPK
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Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-dependent Diabetes of Rabbits
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Resveratrol blocks diabetes-induced early vascular lesions and vascular endothelial growth factor induction in mouse retinas
Cognitive Functioning / Neuro-protection / Alzhimers
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Resveratrol Preserves Cerebrovascular Density and Cognitive Function in Aging Mice
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Protective effects of resveratrol on aging-induced cognitive impairment in rats
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Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection
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Resveratrol—A boon for treating Alzheimer’s disease?
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Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s disease
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Therapeutic potential of resveratrol in Alzheimer’s disease
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Resveratrol, A Neuroprotective Supplement for Alzheimer’s Disease
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Roles of resveratrol and other grape-derived polyphenols in Alzheimer’s disease prevention and treatment
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Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8
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Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease
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Resveratrol and Alzheimer’s disease: message in a bottle on red wine and cognition
Absorption / Bio-availability
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Bioavailability of trans-resveratrol from red wine in humans
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Bioavailability of resveratrol
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Resveratrol bioavailability and toxicity in humans
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Improved Stability of trans-Resveratrol in Aqueous Solutions by Carboxymethylated (1,3/1,6)-β-d-Glucan
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High Absorption but very low Bio-availability of oral Resveratrol in humans
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Metabolism and bio-availability of trans-resveratrol
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Bioactivity of Resveratrol
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Resveratrol Is Absorbed in the Small Intestine as Resveratrol Glucuronide
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Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans
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Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets
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Intestinal Absorption and First-Pass Metabolism of Polyphenol Compounds in Rat and Their Transport Dynamics in Caco-2 Cells
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Development of a Lozenge for Oral Transmucosal Delivery of Trans-Resveratrol in Humans: Proof of Concept
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Absorption of resveratrol by vascular endothelial cells through passive diffusion and an SGLT1-mediated pathway
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Compositions and methods relating to resveratrol ABSORBTION
Cell Effects / Mitochondria
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SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
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The Effect of Resveratrol on a Cell Model of Human Aging
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Mitochondrial Protection by Resveratrol
Skin Disorders
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The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges
Colitis
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Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis
Glaucoma
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Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells
Osteoporosis / Bone Density
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Resveratrol As Anti-Aging Therapy for Age-Related Bone Loss
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Resveratrol Inhibited Inflammation and Alveolar Bone Loss in Periodontitis
Testosterone
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trans-Resveratrol, a Natural Antioxidant from Grapes, Increases Sperm Output in Healthy Rats
